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    复旦校友刘劲松肿瘤研究获重要发现

    Jinsong Liu, M.D., Ph.D.Jinsong Liu, M.D., Ph.D.1983, Shanghai Medical University1991, Case Western Reserve UniversityM. D. Anderson Cancer CenterPathologyResearch Interests: Ovarian and breast cancer model; brca1/brca2 in ovarian and breast cancer development; ovarian cancer diagnostic and prognostic markers The research in my laboratory is directed at understanding of genetic events transforming normal human ovarian and breast epithelial cells into ovarian and breast cancer. A strong focus in my laboratory is to introduce oncogenes into human ovarian or breast epithelial cells in a stepwise manner and create an in vitro model for human ovarian and breast cancer. We are also examining how brca1 or brca2 germline mutation contributes to breast and ovarian cancer development. Second major interest is to identify the novel diagnostic and prognostic markers for human ovarian cancer. We are currently using cDNA microarray to examine the genetic events involved in the transformation from in vitro model and ovarian cancer specimens from ovarian cancer patients. The diagnostic and prognostic markers are compared with ovarian cancer tissue microarray containing hundreds of patients ovarian cancer linked with patients clinical outcome data on a single slide. In this way, we hope to identify early diagnostic markers for ovarian cancer, which can be cured if detected at an early age. Depending on the students interests, a tutorial in my laboratory would provide experience with basic cancer mechanism involved in ovarian and breast cancer development or clinical translational research. Our group has been highly productive (see our publication list) and environment for student’s learning is superb.
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