会大量富集，其中得到证实的是肿瘤抑制子RB1（Retinoblastoma 1）和TGFBR2 (transforming growth factor, beta receptor II)。这说明miRNAs在实体肿瘤的癌症发病机理中发挥着重要的作用。 原文：Published online before print February 3, 2006, 10.1073/pnas.0510565103 PNAS | February 14, 2006 | vol. 103 | no. 7 | 2257-2261 A microRNA expression signature of human solid tumors defines cancer gene targets Stefano Volinia, George A. Calin, Chang-Gong Liu, Stefan Ambs, Amelia Cimmino, Fabio Petrocca, Rosa Visone, Marilena Iorio, Claudia Roldo, Manuela Ferracin, Robyn L. Prueitt, Nozumu Yanaihara, Giovanni Lanza, Aldo Scarpa, Andrea Vecchione, Massimo Negrini, Curtis C. Harris, and Carlo M. Croce
< 1 > < 2 >
|
