Lee,1 Hae Yong Yoo,1 and William G. Dunphy1, 1 Division of Biology 216-76, California Institute of Technology, Pasadena, CA 91125, USAATR is a key regulator of checkpoint responses to incompletely replicated and damaged DNA, but the mechanisms underlying control of its kinase activity are unknown. TopBP1, the vertebrate homolog of yeast Cut5/Dbp11, has dual roles in initiation of DNA replication and regulation of checkpoint responses.
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