Yuan,1,2 Xiaoling Wang,1,2 Joel S. Bader,2,3 and Jef D. Boeke1,2, 1 Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA2 The High Throughput Biology Center, The Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA3 Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218 USAA network governing DNA integrity was identified in yeast by a global genetic analysis of synthetic fitness or lethality defect (SFL) interactions. Within this network, 16 functional modules or minipathways were defined based on patterns of global SFL interactions. Modules or genes involved …………
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